How Does Genetic Variability Affect Drug Metabolism?
Enzymes such as cytochrome P450s (CYPs) play a pivotal role in drug metabolism. Genetic polymorphisms in these enzymes can lead to variations in drug metabolism rates. For example, some individuals may be "poor metabolizers" due to a deficiency in a specific CYP enzyme, while others may be "ultra-rapid metabolizers." This can profoundly impact the [bioavailability](https://www.ncbi.nlm.nih.gov/) and toxicity of drugs, necessitating dosage adjustments based on genetic testing.
