What Are Some Examples of Pharmacogenomics in Toxicology?
Several well-known examples highlight the application of pharmacogenomics in toxicology:
Warfarin: Genetic variations in the VKORC1 and CYP2C9 genes can affect the metabolism and sensitivity to warfarin, a commonly used anticoagulant. Pharmacogenomic testing can help determine the appropriate dose and reduce the risk of bleeding complications. Irinotecan: Polymorphisms in the UGT1A1 gene can influence the metabolism of irinotecan, a chemotherapy drug. Patients with certain genetic variants are at higher risk for severe toxicity, and dose adjustments can be made based on genetic testing. Abacavir: The presence of the HLA-B*5701 allele is associated with a higher risk of hypersensitivity reactions to abacavir, an antiretroviral drug. Genetic testing for this allele can prevent life-threatening adverse reactions.
