What Are the Key Genetic Factors in Drug Toxicity?
Several genetic factors can influence an individual's susceptibility to drug toxicity. These include variations in drug-metabolizing enzymes, drug transporters, and drug targets. For example, polymorphisms in the CYP450 enzymes can affect the metabolism of many drugs, leading to either increased toxicity or reduced efficacy. Similarly, genetic variations in drug transporters like P-glycoprotein can alter drug distribution and elimination.
