What are Some Examples of Polymorphic Variants in Toxicology?
A well-known example is the polymorphic variant in the CYP2D6 gene. This gene encodes an enzyme responsible for the metabolism of many drugs. Variants in CYP2D6 can categorize individuals as poor, intermediate, extensive, or ultra-rapid metabolizers, affecting how they process medications like codeine and antidepressants. Another example is the GSTT1 gene, where certain deletions can impact the detoxification of carcinogens, potentially influencing cancer risk.
