What are Some Examples of Receptor-Mediated Toxicity?
Receptor-mediated toxicity involves toxicants interacting with specific receptors to elicit harmful effects. A classic example is dioxins, which bind to the aryl hydrocarbon receptor (AhR), leading to the expression of genes involved in toxic responses. Another example is organophosphates, which inhibit acetylcholinesterase, causing an accumulation of acetylcholine at synapses and overstimulation of acetylcholine receptors, resulting in neurotoxicity.
