What are the Challenges in Hepatotoxicity Testing?
Despite advances, hepatotoxicity testing faces several challenges:
Species Differences: Results from animal models may not always predict human outcomes due to species-specific metabolic pathways. Complexity of the Liver: The liver’s complex metabolic functions and regenerative capacity make it difficult to fully replicate in vitro. Inter-individual Variability: Genetic differences among individuals can lead to variable responses to hepatotoxic compounds.
