Hepatotoxicity testing involves a series of in vitro and in vivo methods to assess the liver-damaging potential of compounds:
In vitro Testing: This includes using liver cell models like hepatocytes and liver microsomes to evaluate cytotoxicity, enzyme activity, and other cellular responses to a compound. In vivo Testing: Animal models are used to study the effects of compounds on liver function and structure over time. Observations might include changes in liver enzyme levels, histopathology, and other biomarkers of liver injury.
