- Complexity of Materials: Modern materials often have complex compositions, making it difficult to predict their toxicological properties. - Lack of Data: There is often insufficient toxicological data available for new materials, particularly nanomaterials. - Ethical Concerns: The use of animal testing raises ethical issues, necessitating the development of alternative methods. - Interdisciplinary Collaboration: Effective material toxicology requires collaboration between material scientists, toxicologists, and regulatory bodies.