What are the Challenges in Researching Caspases in Toxicology?
One challenge in researching caspases is distinguishing between apoptosis and other forms of cell death, such as necrosis and autophagy. Since caspases are primarily associated with apoptosis, accurate measurement and interpretation are critical. Additionally, off-target effects of caspase inhibitors and the complex interplay between different cell death pathways can complicate studies. Further research is needed to fully understand the role of caspases in toxicological processes and their potential as therapeutic targets.
In conclusion, caspases are integral to understanding apoptosis in toxicology. Their regulation and dysregulation can significantly impact the outcome of toxicological exposures, making them an area of intense study for both understanding mechanisms of toxicity and developing new therapeutic approaches.
