What Are the Challenges in Studying Caspase Activation in Toxicology?
One of the main challenges is the complexity of apoptotic pathways and the numerous factors that can influence caspase activation. Moreover, apoptosis is not the only form of cell death; cells can also undergo necrosis or autophagy in response to toxic insults. Distinguishing between these forms of cell death and understanding their interplay is crucial for a comprehensive toxicological assessment.
