Despite its advantages, targeting in toxicology faces several challenges:
Specificity: Achieving high specificity to target only the desired cells without affecting others remains a major hurdle. Immune response: Some targeting agents can induce an immune response, reducing their efficacy and leading to potential side effects. Complexity and cost: Developing and manufacturing targeted therapies can be complex and costly, which might limit their availability and application. Delivery barriers: Biological barriers, such as the blood-brain barrier, can hinder the delivery of targeted agents to specific sites within the body.
