What are the Challenges of Using iPSCs in Toxicology?
Despite their promise, using iPSCs in toxicology faces several challenges:
Reprogramming Efficiency: The process of generating iPSCs is not always efficient, and the quality of reprogrammed cells can vary. Genetic and Epigenetic Variability: iPSCs may exhibit genetic and epigenetic differences that can affect their differentiation and functional outcomes. Cost and Time: Producing and maintaining iPSCs can be expensive and time-consuming compared to traditional methods. Standardization: There is a need for standardized protocols to ensure consistency and reproducibility in iPSC-based toxicology studies.
