What are the Clinical Implications of UGT Inhibition or Induction?
Clinically, the inhibition or induction of UGTs can have profound implications. For instance, inhibiting UGTs could increase the bioavailability of certain drugs, necessitating dose adjustments to avoid toxicity. On the other hand, inducing UGTs might reduce drug efficacy, requiring higher doses to achieve therapeutic effects. These interactions are particularly relevant in polypharmacy, where multiple drugs may compete for UGT-mediated metabolism.
