In the realm of pharmacology, UGTs significantly affect the pharmacokinetics of drugs. They are responsible for the glucuronidation of a wide range of pharmaceuticals, including nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics, and antidepressants. This process often renders the drugs inactive, thus terminating their therapeutic effects and facilitating their removal. Understanding the activity of specific UGTs can help predict a drug's efficacy and safety profile.
