What are the Current Management Strategies for CINV?
Effective management of CINV involves the use of antiemetic drugs, which are administered before and after chemotherapy sessions. Key classes of antiemetics include:
5-HT3 receptor antagonists (e.g., ondansetron) which block serotonin receptors in the gut and CTZ. NK1 receptor antagonists (e.g., aprepitant) which block substance P from binding to neurokinin receptors. Corticosteroids (e.g., dexamethasone) which enhance the efficacy of other antiemetics. Dopamine antagonists (e.g., metoclopramide) for targeting the dopamine receptors in the brain.
Non-pharmacological approaches, such as dietary modifications, acupuncture, and psychological support, also play a role in managing CINV.
