Hypersensitivity reactions are a significant concern with Taxol administration. These reactions can range from mild skin rashes to severe anaphylactic responses. The cause of these reactions is often attributed to the formulation of Taxol, which contains Cremophor EL, a polyoxyethylated castor oil used as a solvent. To mitigate these reactions, patients are typically premedicated with corticosteroids and antihistamines before receiving Taxol.
