What Are the Implications for Drug Dosing in Hepatic Impairment?
Adjusting drug dosing in patients with hepatic impairment is crucial to avoid toxicity. The degree of dose adjustment depends on the extent of liver dysfunction and the specific drug involved. For example, drugs with a narrow therapeutic index or those extensively metabolized by the liver may require significant dose reductions. Clinicians often refer to guidelines and hepatic impairment-specific pharmacokinetic data to make informed dosing decisions.
