How Does Hepatic Impairment Affect Toxicological Risk Assessment?
In toxicology, assessing the risk of chemical exposure in individuals with hepatic impairment is challenging. The impaired liver function can alter the metabolism and excretion of chemicals, potentially increasing toxicity. Toxicologists must consider the variability in liver function among individuals and incorporate this into risk assessment models. Understanding the impact of hepatic impairment is vital for developing safe and effective drug regimens and exposure guidelines.
