What Are the Implications of Altered Glutathione Peroxidase Activity?
Diminished GPx activity can lead to increased vulnerability to oxidative damage, contributing to the development of various diseases and toxicological outcomes. For instance, decreased GPx activity has been associated with conditions like cancer, cardiovascular diseases, and neurodegenerative disorders. On the other hand, elevated GPx activity may indicate an adaptive response to oxidative stress, although chronic upregulation might have its own adverse effects.
