What Are the Implications of Complement Activation in Drug Toxicity?
Drug-induced complement activation can lead to hypersensitivity reactions, which can manifest as mild skin rashes or severe anaphylactic reactions. For instance, some biologic drugs, because of their protein nature, may be recognized by the immune system as foreign, leading to complement activation. This is a crucial consideration during drug development and safety assessment, as unintended complement activation can significantly affect a drugâs safety profile.
