PARP inhibitors are a class of pharmacological agents that block the activity of PARP enzymes. They are predominantly used in cancer therapy, as they can potentiate DNA damage in cancer cells, leading to cell death. However, from a toxicological perspective, PARP inhibition can also have adverse effects. The inhibition of PARP can affect DNA repair mechanisms in normal cells, potentially leading to increased susceptibility to genomic instability and secondary malignancies.
