In toxicology, the interaction of PAR with cellular components can be significant. Exposure to genotoxic agents can lead to DNA damage, triggering PARP activation to facilitate repair. However, excessive PARP activation can result in cell death due to depletion of cellular NAD+ and ATP, thus contributing to the pathogenesis of various toxicological events. Understanding the role of PAR in these processes aids in the assessment of chemical toxicity and potential therapeutic interventions.
