Despite its advantages, the BMD approach has limitations. The accuracy of a BMD estimate depends on the quality of the dose-response data and the choice of the statistical model. Poor quality data or inappropriate model selection can lead to misleading results. Additionally, the BMD approach assumes that the dose-response relationship is similar across different populations, which may not always be the case due to species differences and interindividual variability. Therefore, careful consideration and expert judgment are required when applying BMD in risk assessments.
