What are the Main Types of ABC Transporters Involved in Toxicology?
Several ABC transporters are of particular interest in toxicology, including:
ABCB1 (P-glycoprotein): Known for its role in drug efflux and multidrug resistance. ABCC (MRP family): Involved in the transport of organic anions and drugs, contributing to drug resistance. ABCG2 (BCRP): Plays a role in the efflux of drugs and xenobiotics, affecting oral drug absorption and cancer resistance.
