What are the Limitations of the Michaelis-Menten Model in Toxicology?
While the Michaelis-Menten model provides a simplified view of enzyme kinetics, it has limitations, especially when applied to complex biological systems. It assumes a single substrate binding site and no cooperative interactions between enzyme molecules. In toxicology, where multiple substrates and inhibitors often compete for the same enzyme, more complex models such as allosteric regulation and enzyme inhibition kinetics may be more appropriate.
