Despite their advantages, topical treatments have limitations:
Limited penetration: Some toxic substances penetrate deeper layers of the skin, where topical treatments may not reach effectively. Potential for local irritation: Some formulations can cause irritation or allergic reactions in sensitive individuals. Variable absorption: Factors like skin integrity, thickness, and hydration can affect the absorption and efficacy of topical treatments. Inadequate for systemic toxicity: Topical treatments are not suitable for addressing systemic toxicity and should be supplemented with other therapeutic approaches when necessary.
