- Variability: Individual differences such as age, gender, and body composition can affect the accuracy of BSA calculations. For instance, the standard formulas may not be suitable for individuals with significant obesity or cachexia.
- Population Specificity: Most BSA formulas are derived from Caucasian populations, which might not accurately represent other ethnic groups due to differences in body composition and stature.
- Complexity in Application: For certain drugs or toxins, other factors like renal or hepatic function might be more critical determinants than BSA.