What are the Mechanisms Behind CAR T Cell Toxicities?
The toxicities associated with CAR T cell therapies primarily arise from the immune system's overactivation. The engineered T cells release cytokines such as IL-6, IL-10, and TNF-alpha, which can lead to a cytokine storm. This uncontrolled immune response can affect multiple organs and systems, explaining the varied manifestations of CRS and neurotoxicity.
