What are the Mechanisms Behind Systemic Inflammation Induced by Toxins?
Toxins can activate systemic inflammation through several mechanisms. One common pathway is the activation of the inflammasome, a multiprotein complex that triggers the production of pro-inflammatory cytokines such as IL-1β and IL-18. Additionally, toxins can cause oxidative stress by generating reactive oxygen species (ROS), which further stimulates inflammatory pathways. Disruption of the immune system by chemicals also plays a crucial role, as it can lead to an aberrant inflammatory response.
