What are the Mechanisms Behind Toxic-Induced Seizures?
The mechanisms by which toxins induce seizures involve several pathways:
- Inhibition of GABAergic Activity: Many toxins reduce the activity of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain, leading to hyperexcitability. - Glutamatergic Overactivity: Excessive stimulation of glutamate receptors can lead to excitotoxicity and seizures. - Ion Channel Disruption: Some toxins alter the function of sodium, potassium, or calcium channels, disrupting normal neuronal signaling.
