What Are the Mechanisms Behind Toxin-Induced Cell Proliferation Changes?
The mechanisms by which toxins alter cell proliferation involve interference with key signaling pathways such as MAPK, PI3K/Akt, and p53. Toxins may activate or inhibit these pathways, leading to aberrant cell cycle control. For example, some pesticides can modulate the expression of cyclins and cyclin-dependent kinases (CDKs), disrupting normal cell cycle progression.
