What Are the Mechanisms of Chemical-Induced Carcinogenesis?
Chemical-induced carcinogenesis typically involves genotoxic mechanisms where DNA damage leads to mutations. These can be caused by direct interaction of chemicals with DNA or through the formation of reactive metabolites. Non-genotoxic mechanisms, such as hormonal imbalances or chronic inflammation, can also promote malignancy by creating an environment conducive to tumor growth. Understanding these mechanisms allows for the development of targeted interventions and therapeutic strategies.
