What are the Mechanisms of Inducing Genomic Instability?
Toxicants can induce genomic instability through various mechanisms. One common pathway is the induction of oxidative stress, which generates reactive oxygen species (ROS) that damage DNA. Another mechanism is the direct interaction with DNA, leading to adduct formation and strand breaks. Additionally, toxicants can interfere with spindle apparatus during cell division, leading to aneuploidy. Understanding these mechanisms helps in assessing the risk and designing intervention strategies.
