What are the mechanisms of Rifampin-induced hepatotoxicity?
Rifampin-induced hepatotoxicity is believed to be mediated by the formation of reactive metabolites during its metabolism in the liver. These metabolites can cause direct cellular damage and trigger immune-mediated liver injury. The risk of hepatotoxicity is increased when rifampin is used in combination with other hepatotoxic drugs, such as isoniazid and pyrazinamide, which are also used in tuberculosis treatment.
