What Are the Mechanisms Underlying Glomerular Hypertension Induced by Toxic Agents?
The mechanisms by which toxic agents induce glomerular hypertension can vary. One primary mechanism is vasoconstriction of the renal arterioles, which increases the pressure within the glomeruli. Another mechanism involves the disruption of the renal endothelial cells, leading to impaired blood flow regulation. Additionally, toxicants may stimulate the production of pro-inflammatory cytokines, contributing to structural changes and increased pressure within the kidney's filtering apparatus.
