Antidotal therapy can be specific or supportive. Specific antidotes, such as naloxone for opioid overdose or atropine for organophosphate poisoning, directly counteract the toxic effects. Supportive antidotes, like N-acetylcysteine for acetaminophen toxicity, work by replenishing depleted substances in the body. The administration of an antidote should be based on the type of toxin, its mechanism of action, and the patient's clinical status.