What are the Primary Research Approaches in Toxicology?
Research in toxicology can be broadly categorized into in vivo, in vitro, and in silico methodologies. Each has its unique advantages and limitations.
In vivo: These are experiments conducted on whole living organisms, such as animal models. In vivo studies provide comprehensive data on the systemic effects of toxins, but ethical considerations and species differences can limit their applicability. In vitro: These involve testing on isolated cells or tissues in a controlled environment. In vitro methods are less expensive and ethically favorable compared to in vivo, though they may not fully replicate an organism's response. In silico: These are computer-simulated experiments. In silico approaches are cost-effective and quick, allowing researchers to predict how toxins might interact with biological systems. However, they require validation against empirical data to ensure accuracy.
