The primary routes of elimination are via the kidneys, liver, and lungs. The kidneys filter the blood to remove waste products and toxins, which are excreted in urine. The liver processes toxins into more water-soluble forms that can be excreted in bile or urine. The lungs can eliminate volatile substances through exhalation. Each of these routes plays a vital role in maintaining the body's homeostasis by preventing the accumulation of harmful substances.