What are the risk factors for Colchicine toxicity?
Certain factors can increase the risk of colchicine toxicity. These include impaired renal or hepatic function, as the drug is metabolized in the liver and excreted through the kidneys. Concurrent use of medications that affect colchicine metabolism, such as CYP3A4 inhibitors, can also elevate toxicity risk. Elderly patients and those with pre-existing conditions are particularly vulnerable.
