Treatment for colchicine toxicity is primarily supportive, as there is no specific antidote. Initial management involves stabilizing the patient with hydration and electrolyte balance. Activated charcoal may be administered if the patient presents within a few hours of ingestion. In severe cases, intensive care support, including mechanical ventilation and renal replacement therapy, may be necessary. Gastrointestinal decontamination and symptomatic treatment are crucial in managing the toxicity.