Despite their therapeutic benefits, antimetabolites can cause a range of toxic effects. The most common toxicities are myelosuppression, gastrointestinal disturbances, and mucositis, which occur due to the drug's impact on rapidly dividing cells. Long-term use can lead to organ-specific toxicities, such as hepatic and renal damage. Monitoring blood counts and organ function is essential for patients undergoing treatment with antimetabolites.
