What are the signs and symptoms of Topiramate toxicity?
The clinical manifestations of topiramate toxicity are varied and can include neurological symptoms such as dizziness, ataxia, confusion, somnolence, and speech difficulties. More severe cases may lead to seizures, coma, or encephalopathy. Other signs can include gastrointestinal symptoms like nausea and vomiting, as well as metabolic acidosis, which is a characteristic finding in significant overdoses. Ocular symptoms such as acute myopia and secondary angle-closure glaucoma have also been reported.
