What are the Sources of Uncertainty and Variability?
Several sources contribute to uncertainty and variability in toxicology:
1. Exposure Assessment: Uncertainty in estimating the level of exposure individuals receive from various sources. 2. Toxicokinetics: Variability in how a substance is absorbed, distributed, metabolized, and excreted by different individuals. 3. Toxicodynamics: Differences in how individuals respond to a toxic substance at the same exposure level. 4. Data Gaps: Lack of data on certain chemicals or effects. 5. Inter-species Differences: Differences between animals used in studies and humans.
