Vitamin B12 deficiency can lead to several health issues. Common symptoms include fatigue, weakness, constipation, loss of appetite, and weight loss. Neurological changes, such as numbness and tingling in the hands and feet, can also occur. Severe deficiency can cause anemia, balance problems, depression, confusion, dementia, poor memory, and soreness of the mouth or tongue. Long-term deficiency may lead to irreversible neurological damage.