Symptoms of folic acid deficiency can be subtle initially but may progress to include fatigue, weakness, headaches, irritability, and difficulty concentrating. In a toxicological context, these symptoms may be exacerbated by exposure to environmental toxins, further impairing an individual's health. Moreover, folic acid deficiency can lead to elevated levels of homocysteine, an amino acid linked to an increased risk of cardiovascular diseases and potentially toxic effects on neural tissues.