While procainamide is effective in treating arrhythmias, it can also lead to potential toxic effects if not properly managed. The most significant toxicological concern is its ability to cause drug-induced lupus erythematosus, a condition that mimics the symptoms of lupus, including fever, joint pain, and skin rash. Additionally, procainamide toxicity can result in proarrhythmia, where it paradoxically causes new or worsened arrhythmias, and agranulocytosis, a severe reduction in the number of white blood cells.
