While prodrugs offer numerous benefits, they also present unique toxicological challenges:
Variable Metabolism: Inter-individual variability in enzyme activity can lead to differences in drug activation and potentially unpredictable pharmacokinetics. Metabolic Interactions: Prodrugs may be involved in drug interactions if they share metabolic pathways with other drugs, potentially leading to increased toxicity or reduced efficacy. Toxic Metabolites: The conversion process might produce toxic intermediates or byproducts that could lead to adverse effects.
