What Are the Toxicological Concerns Associated With Fibrates?
Fibrates are generally well-tolerated, but they can pose several toxicological risks. The most notable concerns include:
Hepatotoxicity: Fibrates have been associated with liver enzyme elevations. In some cases, this can lead to serious liver injury. Regular monitoring of liver function tests is recommended for patients on fibrate therapy. Myopathy: Fibrates may cause muscle toxicity, particularly when used in combination with statins. This can range from mild myalgia to severe rhabdomyolysis. Renal Impairment: These drugs can affect kidney function, especially in patients with pre-existing renal disease. Dose adjustments may be necessary to mitigate this risk. Gallstones: Fibrates can increase the risk of gallstone formation due to alterations in bile acid composition and cholesterol metabolism.
