While many indoles have beneficial effects, some can pose toxicological risks. For example, 3-methylindole, also known as skatole, is a metabolite produced by the degradation of tryptophan in the gut. High levels of skatole have been linked to respiratory distress and other toxic effects in livestock. Furthermore, certain synthetic indole derivatives used in the chemical industry may have carcinogenic or mutagenic properties. Therefore, understanding the safe levels of exposure and proper handling of indoles is crucial in occupational safety.
