There are several reasons why prodrugs are developed:
Enhance Solubility: Many active drugs have poor solubility, limiting their absorption. Prodrugs can be designed to be more water-soluble, facilitating better absorption in the gastrointestinal tract. Improve Absorption and Distribution: By masking polar or ionizable groups, prodrugs can enhance absorption and penetration across biological membranes. Targeted Drug Delivery: Prodrugs can be engineered to activate in specific tissues, reducing systemic side effects and improving therapeutic index. Reduce Toxicity: By controlling the release of the active drug, prodrugs can decrease the potential for toxicity by preventing peaks in drug concentration.
